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This article is part of the supplement: 1st Scientific Meeting of the Head and Neck Optical Diagnostics Society

Open Access Oral presentation

Early experience with in-vivo optical coherence tomography for differentiating lesions of the upper aerodigestive tract

Christian Stephan Betz1*, Veronika Volgger1, Herbert Stepp2, Waseem Jerjes3, Tahwinder Upile3, Andreas Leunig1 and Colin Hopper3

  • * Corresponding author: Christian S Betz

Author Affiliations

1 Department of Otorhinolaryngology, Head & Neck Surgery, Ludwig Maximilian University Munich, Marchioninistr, Munich, Germany

2 Laser-Research Laboratory, LIFE Center, Ludwig Maximilian University, Marchioninistr, Munich, Germany

3 Department of Oral and Maxillofacial Surgery, University College London Hospital, Mortimer Market, London WC1E 6AU, UK

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Head & Neck Oncology 2009, 1(Suppl 1):O15  doi:10.1186/1758-3284-1-S1-O15


The electronic version of this article is the complete one and can be found online at: http://www.headandneckoncology.org/content/1/S1/O15


Published:28 July 2009

© 2009 Betz et al; licensee BioMed Central Ltd.

Objective

In vivo detection of dysplastic or early invasive mucosal changes is expected to greatly reduce both morbidity and mortality of oral and pharyngeal cancer. Optical Coherence Tomography (OCT) seems to be well suited for this application.

Methods

In this ongoing study, 28 patients with a total of 34 primary, flat mucosal lesions of the upper aerodigestive tract (OADT) were prospectively examined using a time-domain, in vivo OCT (Niris®, Imalux Corporation, USA; lateral resolution 25 μm/axial resolution 15 μm) and the results were compared to the histopathological reports on subsequent tissue biopsies from the same areas. Additionally, an intraoral screening was performed on 52 healthy volunteers.

Results

On the OCT images, surface structures such as the keratin and epithelial layer, the epidermal/dermal junction and areas of cellular crowding were clearly identifiable and showed a good correlation to the histopathological slides down to a depth of approximately 1.5 mm. Of 34 lesions investigated so far, 2 out of 2 early malignant lesions as well as 29 out of 32 non-/premalignant lesions could be correctly differentiated using OCT. The screening resulted in a high degree of variability in the physiological thickness of intraoral epithelium (ø126 μm at the floor of mouth to ø487 μm at the lateral border of tongue).

Conclusion

From these results, the method seems to hold great promise for early in vivo tumour diagnosis and depth measurement in early invasion. Further efforts are currently being undertaken for an enhancement of image quality and contrast.