Table 4 |
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Selected up-regulated genes identified in USC-HN1 cells by microarray analysis also present in HNSCC tumor biopsies.* |
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GeneBank Access ID |
Gene Symbol & Annotation |
Log2 Fold Difference** |
|
|
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|
Immune Response |
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MIF, macrophage migration inhibitory factor |
3.1 |
|
|
HLA-A, major histocompatibility complex, class I A |
2.2 |
|
|
IGFBP2, insulin-like growth factor binding protein 2 |
1.7 |
|
|
CD24, CD24 antigen |
1.1 |
|
|
Cell Growth, Maintenance/Cell cycle Regulation |
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|
KRT18, keratin 18 |
6.2 |
|
|
KRT8, keratin 8 |
5.8 |
|
|
CFL1, cofilin 1 |
4.1 |
|
|
PFN1, profilin 1 |
4.0 |
|
|
KRT19, keratin 19 |
3.6 |
|
|
FTL, ferritin, light polypeptide |
3.2 |
|
|
CCT4, chaperonin subunit 4 |
3.2 |
|
|
CDH1, E-cadherin |
2.3 |
|
|
Translation and Protein Synthesis |
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|
RPLP0, ribosomal protein LP0 |
6.3 |
|
|
RPL18, ribosomal protein L18 |
5.5 |
|
|
RPL10, ribosomal protein L10 |
5.2 |
|
|
RPS18, ribosomal protein S18 |
4.9 |
|
|
EIF4G2, translation initiation factor 4 gamma 2 |
4.2 |
|
|
RPL37A, ribosomal protein L37A |
4.0 |
|
|
RPS 3A, ribosomal protein S3A |
3.8 |
|
|
RPL21, ribosomal protein L21 |
3.7 |
|
|
EIF4A2, eukaryotic translation initiation factor 4A |
2.9 |
|
|
EEF1D, eukaryotic translation elongation factor 1D |
1.2 |
|
|
Metabolism |
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|
PKM2, pyruvate kinase, muscle |
5.7 |
|
|
PPIA, peptidylprolyl isomerase A (cyclophilin A) |
4.7 |
|
|
LDHB, lactate dehydrogenase B |
4.4 |
|
|
HSPB1, heat shock 27 kDa protein |
4.2 |
|
|
PPM1G, protein phosphatase 1G |
2.8 |
|
|
ATP5G3, ATP synthase H+ transporting subunit |
2.7 |
|
|
ATP5H, ATP synthase H+ transporting subunit |
2.5 |
|
|
PSMB5, proteasome subunit, beta 5 |
2.4 |
|
|
GPX1, glutathione peroxidase 1 |
2.3 |
|
|
PPP2CA, protein phosphatase 2 catalytic subunit |
2.2 |
|
|
ATP1B3, ATP synthase Na+/K+ transporting, beta 3 |
1.6 |
|
|
FABP5, fat acid binding protein 5 |
1.2 |
|
|
Ion Binding Proteins |
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|
S100A11, S100 calcium binding protein A11 |
1.8 |
|
|
S100A14, S100 calcium binding protein A14 |
1.0 |
|
|
Others |
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|
TMSB10, thymosin, beta 10 |
4.2 |
|
|
ENO1, enolase 1 |
4.0 |
|
|
UBC, ubiquitin C |
3.4 |
|
|
PRDX1, peroxiredoxin 1 |
3.2 |
|
|
NME2, non-metastatic cells 2 protein |
3.1 |
|
|
CD164, CD164 antigen |
2.6 |
|
|
|
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*All selected genes with p-value < 0.05. **Log2 ratio fold-differences between USC-HN1 cells and normal tonsil tissues were determined by subtracting the ratio of genes in normal tonsil tissue versus uRNA from the ratio of genes in USC-HN1 cells versus uRNA. (Log2 ratio of 1 equals to 2-fold difference between USC-HN1 cells and normal tissue; Log2 ratio of 2 equals to 4-fold difference between USC-HN1 and normal tissue, and so on). |
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Liebertz et al. Head & Neck Oncology 2010 2:5 doi:10.1186/1758-3284-2-5 |
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