Open Access Meeting report

At the frontiers of surgery: review

Tahwinder Upile123, Waseem K Jerjes1234, Henricus J Sterenborg15, Brian J Wong16, Adel K El-Naggar17, Justus F Ilgner8, Ann Sandison19, Max J Witjes110, Merrill A Biel111, Robert van Veen5, Zaid Hamdoon234, Ann Gillenwater112, Charles A Mosse113, Dominic J Robinson114, Christian S Betz115, Herbert Stepp116, Lina Bolotine117, Gordon McKenzie1182, Hugh Barr119, Zhongping Chen120, Kristian Berg121, Anil K D'Cruz122, Holger Sudhoff23, Nicholas Stone119, Catherine Kendall119, Sheila Fisher124, Alexander J MacRobert113, Andreas Leunig115, Malini Olivo125, Rebecca Richards-Kortum126, Khee C Soo127, Vanderlei Bagnato128, Lin-Ping Choo-Smith129, Katarina Svanberg130, I Bing Tan131, Brian C Wilson13233, Herbert Wolfsen13334, Irving Bigio135, Arjun G Yodh136 and Colin Hopper124*

Author Affiliations

1 The "Head and Neck Optical Diagnostics Society" Council, Head & Neck Centre, University College Hospital, 250 Euston Road, London, NW1 2PG, UK

2 Department of Surgery, University College London Medical School, London, UK

3 Department of Otolaryngology/Head and Neck Surgery, Barnet and Chase Farm Hospitals NHS Trust, London, UK

4 Unit of Oral & Maxillofacial Surgery, Division of Maxillofacial, Diagnostic, Medical and Surgical Sciences, UCL Eastman Dental Institute, London, UK

5 Center for Optical Diagnostics and Therapy, Erasmus University Medical Center, Rotterdam, the Netherlands

6 The Beckman Laser Institute and Medical Clinic, The University of California Irvine, Irvine, CA, USA

7 Department of Pathology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA

8 Department of Otorhinolaryngology, Plastic Head and Neck Surgery, Aachen University Hospital, RWTH Aachen, Germany

9 Department of Histopathology, Imperial College and The Hammersmith Hospitals, London, UK

10 Department of Oral & Maxilofacial Surgery, University Medical Center Groningen, the Netherlands

11 Virginia Piper Cancer Institute-Abbott Northwestern Hospital, Minnesota, USA

12 Department of Head and Neck Surgery, Division of Surgery, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA

13 National Medical Laser Centre, University College London, London, UK

14 Center for Optical Diagnostics and Therapy, Department of Radiation Oncology, Erasmus University Medical Center, Rotterdam, the Netherlands

15 Department of Otorhinolaryngology, Head & Neck Surgery, Ludwig Maximilian University, Munich, Germany

16 LIFE Center, University Clinic Munich, Munich, Germany

17 Research Centre for Automatic Control (CRAN), Nancy-University, UMR CNRS, France

18 Michelson Diagnostics, 11A Grays Farm Production Village, Grays Farm Road, Orpington, Kent, BR5 3BD, UK

19 Gloucestershire Hospitals NHS Foundation Trust, Gloucester, UK

20 Department of Biomedical Engineering, Beckman Laser Institute, University of California, Irvine, USA

21 Dept. of Radiation Biology, The Norwegian Radium Hospital, Montebello, Norway

22 Department of Oral & Maxillofacial Surgery, Tata Memorial Hospital, Mumbai, India

23 Department of Otorhinolaryngology, Head and Neck Surgery, Klinikum Bielefeld, Bielefeld, Germany

24 Department of Oral & Maxillofacial Surgery, Leeds Dental Institute, Leeds, UK

25 National University of Ireland, Galway, Ireland

26 Department of Bioengineering, Rice University, Houston, USA

27 National Cancer Centre, Singapore 169610, Singapore

28 University of Sao Paulo, Sao Carlos, SP, Brazil

29 National Research Council Canada-Institute for Biodiagnostics, Winnipeg, Manitoba, Canada

30 Division of Oncology, Lund University Hospital, Lund, Sweden

31 Department of Head & Neck Oncology & Surgery, The Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands

32 Division of BioPhysics and BioImaging, Ontario Cancer Institute, Ontario, Canada

33 Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, Canada

34 Division of Gastroenterology and Hepatology, Mayo Clinic, Florida, USA

35 Department of Biomedical Engineering, Electrical & Computer Engineering, Physics, Boston University, Boston, USA

36 Physics and Astronomy, University of Pennsylvania, Philadelphia, USA

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Head & Neck Oncology 2011, 3:7  doi:10.1186/1758-3284-3-7

Published: 9 February 2011

Abstract

The complete surgical removal of disease is a desirable outcome particularly in oncology. Unfortunately much disease is microscopic and difficult to detect causing a liability to recurrence and worsened overall prognosis with attendant costs in terms of morbidity and mortality. It is hoped that by advances in optical diagnostic technology we could better define our surgical margin and so increase the rate of truly negative margins on the one hand and on the other hand to take out only the necessary amount of tissue and leave more unaffected non-diseased areas so preserving function of vital structures. The task has not been easy but progress is being made as exemplified by the presentations at the 2nd Scientific Meeting of the Head and Neck Optical Diagnostics Society (HNODS) in San Francisco in January 2010. We review the salient advances in the field and propose further directions of investigation.